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KMID : 0381120110330030217
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Genes and Genomics
2011 Volume.33 No. 3 p.217 ~ p.217
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Complete nisin A gene cluster from Lactococcus lactis M78 (HM219853) ? obtaining the nucleic acid sequence and comparing it to other published nisin sequences
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Trmcic Aljosa
Samelis John
Monnet Christophe
Rogelj Irena
Matijasic Bojana Bogovic
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Abstract
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Nisin is an antimicrobial peptide produced by Lactococcus lactis. It has a long history of safe use, mainly in food production. This bacteriocin has been studied from many aspects of genetics, biosynthesis, immunity, regulation and mode of action. The strain Lac. lactis M78 has already been described in previous studies as a good nisin A producer with equally good potential to be used in food production. The main objective of the present study was to determine the complete nucleic acid sequence of the nisin A gene cluster from this strain. This is the first time that all 11 genes that form the nisin A gene cluster were sequenced. The obtained sequence (GenBank: HM219853) was compared to other known nucleic acid sequences of bacteriocin nisin. The results of the comparison showed certain differences in sequences that might influence the structure and function of proteins involved in nisin biosynthesis, immunity and regulation.
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KEYWORD
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Nisin, nucleic acid sequence, Lactococcus lactis
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